| 产品详情 |
| Edit |   |
|---|
| Product Name | FGF-23, Recombinant, Human |
|---|
| Description | Purity >90% (SDS-PAGE). FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC). Biological Activity: Activates ERK and FRS2alpha phosphorylation in Klotho expressing cells. Sequence: Signal peptide and human FGF-23 (aa 1-251) are fused at the C-terminus to a His-tag. Molecular Weight: ~35kD (SDS-PAGE, full-length). FGF23 is cleaved between arg179 and ser 180 (~20kD). |
|---|
| Size | 10ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | FGF-23, Recombinant, Human (His) (Fibroblast Growth Factor 23, Tumor-derived Hypophosphatemia-inducing Factor) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 44810 |
|---|
| Price | |
|---|
| Order / More Info | FGF-23, Recombinant, Human from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|