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| Product Name | FGF23, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). FGF-23 is a protein of 30kD that is proteolytically processed to generate smaller N-terminal (18kD) and C-terminal (12kD) fragments. The N-terminal fragment of FGF-23 contains the FGF receptor (FGFR)-binding domain. In vivo studies using synthetic peptides have indicated that neither of the processed N-terminal or C-terminal fragments of FGF-23 can influence serum phosphate levels. FGF-23 can decrease the activity of NaPi-2a and NaPi-2c cotransporters to reduce renal phosphate reabsorption and thereby can increase urinary phosphate excretion. Similarly, FGF-23 can suppress the expression of 1-alpha-hydroxylase to reduce the production of the active vitamin D metabolite 1,25(OH)2D. Moreover, FGF-23 can also induce 24- hydroxylase, which degrades 1,25(OH)2D Source: Recombinant protein corresponding to human FGF23 expressed in E. coli. Molecular Weight: ~23kD Biological Activity: The ED50 was determined by the dose-dependent proliferation of mouse 3T3 cells expressing FGF receptors, and |
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| Size | 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | FGF23, Recombinant, Human (FGF-23, Phosphatonin, Tumor-Derived Hypophosphatemia-Inducing Factor, HYPF, Fibroblast Growth Factor 23) |
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| Gene, Accession, CAS # | SwissProt: ugZV9 |
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| Catalog # | 499999 |
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| Order / More Info | FGF23, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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