| 产品详情 |
| Edit |   |
|---|
| Product Name | Cyclin C, Recombinant, Human, His-Tag (CCNC) |
|---|
| Description | Purity ~98% (SDS-PAGE). rCCNC (cyclin C) is a member of the cyclin family of proteins. This protein interacts with cyclin-dependent kinase 8 (CDK8) and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this protein peaks in the G1 phase of the cell cycle. It has been shown that a non-cdk8-associated cellular pool of CCNC combines with cdk3 to stimulate pRb phosphorylation at S807/811 during the G0/G1 transition, and that this phosphorylation is required for cells to exit GO efficiently. Other results have shown that a marked elevated immunoreactivity of CCNC was found both in neurons and astrocytes in Alzheimer's disease (AD). Increased levels of CCNC RNA were detected by ribonuclease protection assay (RPA) in severe AD cases and colocalization of CCNC and its preferred binding partner, CDK8, was only observed in astrocytes but not in neurons. Source: Recombinant protein corresponding to full length human Cyclin |
|---|
| Size | 2ug, 10ug |
|---|
| Concentration | n/a |
|---|
| Applications | ELISA IP WB |
|---|
| Other Names | n/a |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 299351 |
|---|
| Price | |
|---|
| Order / More Info | Cyclin C, Recombinant, Human, His-Tag (CCNC) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|