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| Product Name | MerTK, Fc Chimera, Recombinant, Human |
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| Description | Purity ~90% (SDS-PAGE, reducing conditions and visualized by silver stain). Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken c-Eyk) constitute a receptor tyrosine kinase subfamily. The extracellular domains of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. These receptors bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration or the prevention of apoptosis. Recent studies suggest that this family of tyrosine kinase receptors may be involved in hematopoiesis, embryonic development, tumorigenesis and regulation of testicular functions. Sequence Information: Human Mer, Arg26-Ala499 (Accession #Q12866) - IEGRMD - Human IgG1 (Pro100-Lys330) Predicted Molecular |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | MerTK, Fc Chimera, Recombinant, Human (Mer, Receptor Tyrosine Protein Kinase Mer, c-Eyk, c-mer proto-oncogene tyrosine kinase, C-mer, EC 2.7.10, EC 2.7.10.1, MER receptor tyrosine kinase, MER, Receptor tyrosine kinase MerTK, RP38 Proto-oncogene c-Mer, STK kinase, Tyrosine-protein kinase Mer) |
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| Gene, Accession, CAS # | Gene ID: 10461 (Human); 17289 (Mouse), SwissProt: Q12866 |
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| Catalog # | 350864 |
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| Order / More Info | MerTK, Fc Chimera, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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