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| Product Name | BMP11, Recombinant, Human |
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| Description | Purity ~98% (SDS-PAGE and HPLC). GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves arrest of progenitor cell-cycle in the G1 phase. Similarities between myostatin and GDF-11, which are 90% identical in their aa sequence, suggests that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same. Recombinant human GDF-11 is a 25kD disulfide-linked homodimer containing two 109aa polypeptide chains. It is highly homologous to myostatin/GDF-8 sharing 90% aa sequence identity. Source: Recombinant protein corresponding to human GDF-11, expressed in E.coli. Biological Activity: The ED50 was determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 0.08-0.10ug/ml. Endotoxin: <0.1ng/ug (1EU/ug) AA Sequence: |
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| Size | 5ug, 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | BMP11, Recombinant, Human (Growth/Differentiation Factor 11, GDF-11, Bone Morphogenetic Protein 11, BMP-11, GDF11) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 149601 |
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| Order / More Info | BMP11, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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