| 产品详情 |
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| Product Name | Recombinant Human Transcription factor 7-like 2 (TCF7L2), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 54.9kDa. Partial: 1-456aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | HMG box transcription factor 4; T-cell-specific transcription factor 4; T-cell factor 4; TCF-4; hTCF-4 |
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| Gene, Accession, CAS # | TCF7L2, UniProt: Q9NQB0 |
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| Catalog # | RPC23723 |
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| Price | |
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| Order / More Info | Recombinant Human Transcription factor 7-like 2 (TCF7L2), partial from BIOMATIK |
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| Product Specific References | n/a |
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