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| Product Name | Recombinant Human Transmembrane prolyl 4-hydroxylase (P4HTM) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 70.5kDa. Full Length of Isoform 3: 82-563aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Hypoxia-inducible factor prolyl hydroxylase 4; HIF-PH4; HIF-prolyl hydroxylase 4; HPH-4 |
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| Gene, Accession, CAS # | P4HTM, UniProt: Q9NXG6 |
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| Catalog # | RPC23655 |
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| Order / More Info | Recombinant Human Transmembrane prolyl 4-hydroxylase (P4HTM) from BIOMATIK |
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| Product Specific References | n/a |
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