| 产品详情 |
| Edit |   |
|---|
| Product Name | Recombinant Rat Ephrin-A1 (Efna1) |
|---|
| Description | Purity > 90% as determined by SDS-PAGE. MW: 21.4kDa. Full Length of Mature Protein: 18-182aa. N-terminal 6xHis-tagged. Rattus norvegicus (Rat). Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assbly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of bryonic neuronal growth cone and regulates dendritic spine morphogenesis. |
|---|
| Size | 100ug |
|---|
| Concentration | n/a |
|---|
| Applications | RUO |
|---|
| Other Names | EPH-related receptor tyrosine kinase ligand 1; LERK-1Immediate early response protein B61 |
|---|
| Gene, Accession, CAS # | Efna1, UniProt: P97553 |
|---|
| Catalog # | RPC24641 |
|---|
| Price | |
|---|
| Order / More Info | Recombinant Rat Ephrin-A1 (Efna1) from BIOMATIK |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|