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| Product Name | BCAS2, 1-225aa, Human, His tag, E.coli |
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| Description | Purity: > 85% by SDS - PAGE Format: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 20% glycerol, 5mM DTT, 0.2M NaCl.. BCAS2, also known as pre-mRNA-splicing factor SPF27, is a ubiquitously expressed nuclear protein that was originally identified as being overexpressed in various breast cancer cell lines. It is now known to be a component of the spliceosome, participating in the removal of introns from mRNA precursors. BCAS2 specifically interacts (in a ligand-independent manner) with TRbeta (thyroid hormone receptor beta), ERalpha (estrogen receptor alpha), ERbeta, PR (progesterone receptor) and PPARgamma (peroxisome proliferator-activated receptor gamma). This protein functions as an ER co-activator and is capable of enhancing ER-mediated transcription. This suggests that BCAS2 is involved in the development of breast cancer. Recombinant human BCAS2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
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| Size | 50ug, 10ug, |
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| Concentration | n/a |
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| Applications | SDS-PAGE |
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| Other Names | pre-mRNA-splicing factor SPF27, DAM1, Snt307, SPF27 |
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| Gene, Accession, CAS # | NP 005863 |
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| Catalog # | ATGP0914 |
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| Order / More Info | BCAS2, 1-225aa, Human, His tag, E.coli from ATGen |
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| Product Specific References | n/a |
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