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| Product Name | Recombinant Human Insulin-like growth factor-binding protein 5 protein (IGFBP5) (Active) |
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| Description | Purity > 95% as determined by SDS-PAGE. MW: 30.99kDa. Partial: 18-286aa. C-terminal 6xHis-tagged. Homo sapiens (Human). Cytotoxic and Regulatory T-Cell Molecule (CRTAM) is a member of Nectin family under the immunoglobulin superfamily that is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and it is highly expressed by Purkinje cells of the cerebellum. CRTAM is a type I transmembrane glycoprotein containing one Ig-like C2-type domain and one Ig-like V-type domain in its extracellular domain, while its cytoplasmic region shows a potential class I PDZ domain. CRTAM is expressed as a homodimer on the cell surface but does not show homotypic binding in trans. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions. IGSF4 and T cell receptor coengagement of CD8+ cells expressiong CRTAM induces increased IFN? or IL-22 production. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Cytotoxic and Regulatory T-Cell Molecule; Class-I MHC-Restricted T-Cell-Associated Molecule; CD355; CRTAM |
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| Gene, Accession, CAS # | CRTAM, UniProt: O95727 |
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| Catalog # | RPC26990 |
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| Order / More Info | Recombinant Human Insulin-like growth factor-binding protein 5 protein (IGFBP5) (Active) from BIOMATIK |
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| Product Specific References | n/a |
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