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| Product Name | Mouse HMGB1 Carrier-Free (High Mobility Group Box 1) Recombinant Protein |
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| Description | Mouse HMGB1 Carrier-Free (High Mobility Group Box 1) Recombinant Protein, eBioscience™. HMGB1 (High-mobility group box-1) protein was originally described as a nuclear non-histone DNA binding chromosomal protein. However, recent studies indicate that damaged, necrotic cells liberate HMGB1 into the extracellular milieu where it functions as a proinflammatory cytokine. Mouse HMGB1 is expressed as a 215 amino acid single chain polypeptide containing three domains: two tandem-linked positively charged DNA-binding domains (HMG box A, aa 9-79; and box B, aa 89-162), and a negatively charged 30 aa C-terminal acidic tail region. Residues 28 - 44 and 180 - 185 contain a nuclear localization signal (NLS). The cytokine activity of HMGB1 is conta |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | Control: Assay-Dependent, Functional Assay: Assay-Dependent |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Entrez: 15289; Uniprot: P63158 |
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| Catalog # | 34-8401-85 |
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| Order / More Info | Mouse HMGB1 Carrier-Free (High Mobility Group Box 1) Recombinant Protein from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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