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| Product Name | Recombinant Human Interleukin-36 receptor antagonist protein (IL36RN) (Active) |
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| Description | Purity > 95% as determined by SDS-PAGE and HPLC. MW: 16.8kDa. Full Length of Mature Protein: 2-155aa. tag-Free. Homo sapiens (Human). Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. {ECO:0000269|PubMed:11466363, ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:23147407}. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | IL-36Ra, IL-1-related protein 3, IL-1RP3, Interleukin-1 HY1, IL-1HY1 |
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| Gene, Accession, CAS # | IL36RN,FIL1D,IL1F5,IL1HY1,IL1L1,IL1RP3,UNQ1896/PRO4342, UniProt: Q9UBH0 |
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| Catalog # | RPC26518 |
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| Order / More Info | Recombinant Human Interleukin-36 receptor antagonist protein (IL36RN) (Active) from BIOMATIK |
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| Product Specific References | n/a |
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