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| Product Name | Recombinant Human Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (ISCU) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 45.0kDa. Full Length: 1-167aa. N-terminal GST-tagged. Homo sapiens (Human). Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU. In a second step, the cluster is released from ISCU, transferred to a glutaredoxin GLRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISCU depends on the function of the cysteine desulfurase complex NFS1-LYRM4/ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | NifU-like N-terminal domain-containing protein; NifU-like protein |
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| Gene, Accession, CAS # | ISCU, UniProt: Q9H1K1 |
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| Catalog # | RPC25899 |
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| Order / More Info | Recombinant Human Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (ISCU) from BIOMATIK |
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| Product Specific References | n/a |
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