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| Product Name | Recombinant Human Kelch-like ECH-associated protein 1 (KEAP1) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 71.7kDa. Full Length: 1-624aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Cytosolic inhibitor of Nrf2 |
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| Gene, Accession, CAS # | KEAP1, UniProt: Q14145 |
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| Catalog # | RPC24774 |
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| Order / More Info | Recombinant Human Kelch-like ECH-associated protein 1 (KEAP1) from BIOMATIK |
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| Product Specific References | n/a |
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