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| Product Name | MGMT, Recombinant, Human, active (O6-Methylguanine DNA Methyltransferase) |
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| Description | Purity ≥90%. Many tumor promoting/causing agents (BCNU, CCNU, DTIC, procarbazine, temozolomide, etc) generate lethal cross-links at the O6-alkylguanine position in DNA. MGMT (O6-Methylguanine DNA Methyltransferase) removes alkyl adducts from the O6-position of guanine in DNA (prior to cross-link formation) to its cysteine residue, thereby irreversibly inactivating MGMT. Inactivated MGMT is rapidly degraded. Therefore, MGMT levels serves as an indicator of DNA damage. Tumors with high level of MGMT are likely to be drug resistant and low or no MGMT may make the tumor more responsive to chemotherapy. In normal cells, Abnormally low level of MGMT may make normal cells/tissue more susceptible to tumor promoting/alkylating agents. Specific Activity: Minimum 10,000 Units/mg protein. One unit is defined as the amount of protein that cleaves 50% of 0.5 pmole of dsDNA oligomer substrate (O6-methylguanine) in 10 min at 37°C. |
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| Size | 5ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | M3884-92E |
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| Order / More Info | MGMT, Recombinant, Human, active (O6-Methylguanine DNA Methyltransferase) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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