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| Product Name | MGMT, Recombinant, Human, Western BlotPositive Control (O6-methylguanine-DNA methyltransferase) |
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| Description | Many tumor promoting/causing agents (BCNU, CCNU, DTIC, procarbazine, temozolomide, etc) generate , lethal cross-links at the O6-alkylguanine position in DNA. MGMT removes alkyl adducts from the O6-position of guanine in DNA (prior to cross-link formation) to its cysteine residue, thereby irreversibly inactivating MGMT. Inactivated MGMT is rapidly degraded. Therefore, MGMT levels serves as an indicator of DNA damage. Tumors with high level of MGMT are likely to be drug resistant and low or no MGMT may make the tumor more responsive to chemotherapy. In normal cells, Abnormally low level of MGMT may make normal cells/tissue more susceptible to tumor promoting/alkylating agents. Source: Recombinant human MGMT (aa207), expressed in E. coli. Molecular Weight: ~25kD Applications: Suitable for use in Western Blot. Not suitable for use in ELISA. |
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| Size | 100ul |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | M3884-89A |
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| Order / More Info | MGMT, Recombinant, Human, Western BlotPositive Control (O6-methylguanine-DNA methyltransferase) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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