| 产品详情 |
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| Product Name | HA1077 |
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| Description | Purity ~90%. A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced contraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho-associated Kinase (ROCK). HA1077 is an inhibitor of ROK/ROCK II (IC50 1.9uM), PRK2 (IC50 4uM), MSK1 (IC50 5uM), Rsk2 (IC50 15uM), PKA, p70 S6 Kinase, CaM Kinase (Ki 1.8nM) and MLCK (Ki 20nM). HA1077 is a calcium antagonist and has antivasospastic properties. Inhibits ROKa/ROCK II, PRK2, MSK1, Rsk2, PKA, p70 S6 Kinase, CaM Kinase and MLCK. Solubility: Methanol, Water |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | HA1077 (Fasudil, 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine•2HCl, 1-(5-Isoquinolinesulfonyl) homopiperazine•2HCl) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | H1000 |
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| Price | |
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| Order / More Info | HA1077 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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