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| Product Name | TIMM8A, 1-97aa, Human, His tag, E.coli |
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| Description | Purity: >90 % by SDS - PAGE Format: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% glycerol, 1mM DTT. TIMM8A is involved in the import and insertion of hydrophobic membrane proteins from the cytoplasm into the mitochondrial inner membrane. The gene is mutated in Mohr-Tranebjaerg syndrome/Deafness Dystonia Syndrome (MTS/DDS) and it is postulated that MTS/DDS is a mitochondrial disease caused by a defective mitochondrial protein import system. Defects in this gene also cause Jensen syndrome; an X-linked disease with opticoacoustic nerve atrophy and muscle weakness. This protein, along with TIMM13, forms a 70 kDa heterohexamer. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Recombinant human TIMM8A proten, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
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| Size | 0.5mg, 100ug, 20ug |
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| Concentration | n/a |
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| Applications | SDS-PAGE |
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| Other Names | Mitochondrial import inner membrane translocase subunit Tim8 A, Mitochondrial import inner membrane translocase subunit Tim8 A, DDP, DDP1, DFN1, MTS, TIM8 |
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| Gene, Accession, CAS # | NP 004076 |
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| Catalog # | ATGP2486 |
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| Order / More Info | TIMM8A, 1-97aa, Human, His tag, E.coli from ATGen |
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| Product Specific References | n/a |
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