| 产品详情 |
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| Antigenic Specificity | BCL10 |
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| Clone | P84F8 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgG1, κ |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blot (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-BCL10. BCL10 (B cell lymphoma 10), together with CARMA1 (CARD11) and lymphoid tissue lymphoma-translocation gene 1 (MALT1) are signaling proteins. They have a key role in antigen-receptor-mediated lymphocyte activation through the NF-κB pathway. Activation of NF-κB is essential for the immune system to function normally. Deregulated NF-κB in lymphocytes can lead to immunodeficiency, but also to autoimmunity or lymphomas. Phosphorylation of the CARMA1 and BCL10 proteins and ubiquitylation of BCL10 affect the formation and stability of the CARMA1-BCL10-MALT1 (CBM) complex, and also control negative feedback regulation of the NF-κB signaling pathway. Also, recent studies point out an unexpected role for BCL10 in the regulation of the actin cytoskeleton. |
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| Immunogen | Purified recombinant fragment of human BCL10 expressed in E. Coli. |
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| Other Names | B-Cell CLL/Lymphoma 10, B-Cell Lymphoma/Leukemia 10, Bcl-10, BCL-10, CARD Containing Molecule Enhancing NF-KB, CLAP, Me10, CIPER, c-E10, CARMEN, IMD37 |
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| Gene, Accession # | Gene ID: 8915 |
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| Catalog # | 684702 |
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| Price | |
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| Order / More Info | BCL10 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 产品资料 |
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