| 产品详情 |
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| Product Name | GSK126 |
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| Description | A potent, highly selective, S-adenosyl-methionine(SAM)-competitive, small-molecule inhibitor of EZH2 methyltransferase activity. GSK126 is highly selective against other methyltransferases and multiple other protein classes, even 150-fold more selective for the closest EZH1 (Kiapp = 89 nM) and more than 1,000-fold selective for 20 other human methyltransferases, including both SET-domain-containing and non-SET domain-containing methyltransferases. It decreases global H3K27me3 levels and reactivates silenced polycomb repressive complex 2 (PRC2) target genes. MW: 526.67. Purity 100% by chiral HPLC & >99% by HPLC |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (S)-1-(sec-butyl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide |
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| Gene, Accession, CAS # | CAS: 1346574-57-9 |
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| Catalog # | 2282-1 |
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| Price | |
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| Order / More Info | GSK126 from BIOVISION, INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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