| 产品详情 |
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| Antigenic Specificity | Wnt3A |
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| Clone | BL28556 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2b, κ |
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| Format | purified |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | Western Blot (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-Wnt3A. Wnt3a, one of Wnt family members, plays a key role in carcinogenesis. Studies have shown that Wnt3a can both promote and suppress cancer progression depending on the cancer type. Mechanistically, Wnt3a activates downstream signaling pathways in a canonical manner by binding to its receptor Frizzled (Fz) and co-receptor lipoprotein receptor-related proteins 5/6 (LRP5/6), which ultimately promote nuclear translocation of the transcription factor b-catenin. Wnt3A is also involved in non-oncogenic pathways. It modulates brain-derived insulin by increasing NeuroD1 expression levels. Following traumatic brain injury, Wnt3A secreted by mesenchymal stem cell was shown to be neuroprotective and promote neurocognitive recovery. |
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| Immunogen | n/a |
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| Other Names | Protein Wnt-3a |
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| Gene, Accession # | Gene ID: 89780 |
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| Catalog # | 855601 |
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| Price | |
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| Order / More Info | Wnt3A Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 产品资料 |
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