| 产品详情 |
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| Antigenic Specificity | SIAH1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | Western Blot: 1-5 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | SIAH1 Polyclonal Antibody. Seven in absentia homolog 1 (SIAH-1) is a member of the RINGfinger- containing E3 ubiquitin ligases. Alpha-synuclein and synphilin-1 are substrates of SIAH-1. Both proteins are involved in the development of Parkinson's disease (PD). Mutations in Parkin, another E3 ubiquitin ligase which ubiquinates synphilin-1 and glycosylated alpha-synuclein, have been defined as a major cause of autosomal recessive PD. The role of SIAH-1 in PD is highlighted by the fact that SIAH-1 is a component of the Lewy bodies and plays a role in apoptosis caused by nitric oxide (NO) induced oxidative stress. |
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| Immunogen | n/a |
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| Other Names | HUMSIAH, Siah-1, Siah-1a, hSIAH1 |
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| Gene, Accession # | Entrez: 6477; Uniprot: Q8IUQ4 |
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| Catalog # | PA1-12863 |
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| Price | |
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| Order / More Info | SIAH1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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