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| Product Name | Recombinant Human Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 53.7kDa. Extracellular Domain: 31-373aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma mbrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Brain Ig-like molecule with tyrosine-based activation motifs; BitCD172 antigen-like family member AInhibitory receptor SHPS-1Macrophage fusion receptorMyD-1 antigen; Signal-regulatory protein alpha-1; Sirp-alpha-1Signal-regulatory protein alpha-2; Sirp-alpha-2Signal-regulatory protein alpha-3; Sirp-alpha-3p84; CD172a |
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| Gene, Accession, CAS # | SIRPA, UniProt: P78324 |
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| Catalog # | RPC22002 |
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| Price | |
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| Order / More Info | Recombinant Human Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA), partial from BIOMATIK |
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| Product Specific References | n/a |
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