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| Product Name | KIR2DS4, Fc Chimera, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). KIR2DS4 (2DS4), previously called NKAT-8 and designated CD158i, is a type I transmembrane glycoprotein that belongs to the killer cell Ig-like receptor (KIR) family. KIRs are expressed on CD56dim NK cells and T cell subsets where they differentiate normal from abnormal cells and regulate effector functions in the innate immune system. KIRs are named for the number of Ig-like domains (2D or 3D) in the extracellular domain (ECD), and whether they have long or short (L, S) cytoplasmic tails. KIR2DS4 cDNA encodes 304aa including a 21aa signal sequence, a 224aa ECD, a 20aa transmembrane sequence and a 39aa cytoplasmic domain. KIR receptors have no structural orthologs in nonprimates, although mouse 49aa proteins perform similar functions. Like other activating KIRs, KIR2DS4 has a short tail and a positively charged aa within the transmembrane domain that interacts with the ITAM-bearing signaling adaptor, DAP12. Expression of activating KIR is balanced with inhibitory |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | KIR2DS4, Fc Chimera, Recombinant, Human (Killer Cell Immunoglobulin-Like Receptor 2DS4, CD158 Antigen-like Family Member I, MHC Class I NK Cell Receptor, Natural Killer-associated Transcript 8, NKAT-8, P58 Natural Killer Cell Receptor Clones CL-39/CL-17, p58 NK Receptor CL-39/CL-17, CD158i, KKA3, NKAT8) |
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| Gene, Accession, CAS # | SwissProt: P43632 |
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| Catalog # | K1858-60A |
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| Order / More Info | KIR2DS4, Fc Chimera, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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