| 产品详情 |
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| Product Name | Kir2.1 Inhibitor, ML133 (Inward Rectifier Potassium Channel Blocker, ML133) |
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| Description | Purity ~95% (HPLC). A cell-permeable, renal outer medullary potassium (ROMK) blocker that is shown to inhibit inward rectifier potassium channel, Kir2.1 (IC50=1.8uM and 290nM, at pH 7.4 and pH 8.5, respectively). It exhibits little selectivity against other members of the Kir2.x family, but has no effect on Kir1.1 (IC50 >300uM) and displays weak activity for Kir4.1 and Kir7.1 (IC50=76uM and 33uM, respectively). It is reported to be assayed in 218 MLPCN HTS campaigns, demonstrating activity in only two assays that are not based on Kir2.1. Furthermore, it displays a relatively clean profile in a radioligand binding panel of 68 GPCRs, ion channels and transporters. Formula: C19H19NO Molecular Weight: 277.36 Solubility: DMSO (10mg/ml, clear, colorless solution) |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217492 |
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| Order / More Info | Kir2.1 Inhibitor, ML133 (Inward Rectifier Potassium Channel Blocker, ML133) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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