| 产品详情 |
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| Product Name | SYK Inhibitor; R406 |
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| Description | MW: 470.45. Purity ≥98% by HPLC. R406 is a potent SYK (Spleen Tyrosine Kinase) inhibitor (IC50 = 41 nM). R406 strongly inhibits SYK but not Lyn; and displays 5-fold less potency towards FLT3. R406 induces apoptosis in diffuse large B-cell lymphoma cell lines. It blocks B cell receptor signaling through inhibition of SYK autophosphorylation of Y525/Y526 and SYK-dependent phosphorylation of the B-cell linker protein. |
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| Size | 5 mg, 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [6- ( (5-fluoro-2- ( (3; 4; 5-trimethoxyphenyl) amino) pyrimidin-4-yl) amino)-2; 2-dimethyl-2H-pyrido[3; 2-b][1; 4]oxazin-3 (4H)-one] |
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| Gene, Accession, CAS # | CAS: 841290-80-0 |
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| Catalog # | MBS845861 |
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| Order / More Info | SYK Inhibitor; R406 from MYBIOSOURCE INC. |
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| Product Specific References | n/a |
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