| 产品详情 |
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| Product Name | Eliglustat (hemitartrate) |
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| Description | A potent and selective inhibitor of glucosylceramide synthase (IC50 = 40 nM for reduction of glucosylceramide synthesis in K562 cells); inhibits glucosylceramide synthase to reduce production of GM1 and GM3 on K562 and B16/F10 cells (IC50s = 24 and 29 nM, respectively); has minimal activity (IC50 = >10 µM) at α-glucosidase I and II, GBA1, GBA2, sucrase, and maltase; induces a dose-dependent decrease in glucosylceramide accumulation in the liver and lungs of D409V/null mice, a model of Gaucher disease; prevents further glucosylceramide accumulation if administered after liver and lung deposits have been established |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Genz-112638 |
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| Gene, Accession, CAS # | CAS: 928659-70-5 |
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| Catalog # | 21487-25 |
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| Price | |
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| Order / More Info | Eliglustat (hemitartrate) from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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