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| Product Name | Recombinant Mouse P-Selectin (CD62P)-Fc Chimeric (carrier-free) |
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| Description | P-Selectin, an adhesion molecule, belongs to the selectin/LECAM family. P-Selectin consists of one Lectin domain and several EGF-like repeats, which are followed by a transmembrane region and a short cytoplasmic tail of 35 amino acids. P-Selectin is expressed in endothelial cells and megakaryocytes. In unstimulated cells, P-Selectin is synthesized and stored in the alpha-granules of platelets and the Weibel-Palade bodies of endothelial cells. Upon activation or exposure of stimuli, such as thrombin and histamine, P-Selectin is rapidly translocated from storage granule to the cell membrane within minutes and then is recycled back via endocytosis. Inflammatory stimuli, including TNF-α and endotoxins, can induce P-Selectin expression at the transcriptional and protein levels in mouse endothelial cells, but not in HUVEC. IL-4 and oncostatin M can induce P-Selectin expression in HUVEC cells. Surface P-Selectin binds to its ligand, PSGL-1, which is a glycoprotein that is expressed in neutrophils, monocytes, and dendritic cells. Its interaction initiates cell contact and selectin-mediated leukocyte rolling on the endothelial cells’ surfaces. In addition, some evidence has been shown that P-Selectin contributes to cancer metastasis. The interaction between tumor cells and platelets via P-Selectin facilitates adhesion of tumor cells in the vasculature. |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | CD62 antigen-like family member P (CD62P), Granule membrane protein 140 (GMP-140), Leukocyte-endothelial cell adhesion molecule 3 (LECAM3), Platelet activation dependent granule-external membrane protein (PADGEM) |
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| Gene, Accession, CAS # | Gene ID: 20344 |
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| Catalog # | 755402 |
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| Order / More Info | Recombinant Mouse P-Selectin (CD62P)-Fc Chimeric (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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