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| Product Name | Epidermal Growth Factor, Pro-, Recombinant, Mouse (Pro-EGF, EGF) |
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| Description | Purity ≥ 95%, as determined by SDS-PAGE and visualized by silver stain. EGF is the prototypic member of a family of growth factors that also includes amphiregulin, betacellulin, epigen, epiregulin, HB-EGF, neuregulins-1 through -6, and TGF-α (1). These proteins contain EGF-like domains with three intramolecular disulfide bonds between conserved cysteines (2). EGF family members are synthesized as transmembrane preproproteins with varying numbers of EGF-like domains (3). The extracellular region of mouse pro-EGF contains eight LDL R class B repeats and nine EGF-like domains (4). Mature EGF is derived from the juxtamembrane EGF-like domain. EGF binds ErbB1 and induces the formation of homodimers or heterodimers containing ErbB2 (5). pro-EGF is most highly expressed in the submaxillary gland and kidney (6). In the kidney, the 190 kD preproprotein is cleaved by membrane-associated serine proteases, liberating the extracellular region which is subsequently processed into smaller fragm |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P01132 |
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| Catalog # | E3374-11P |
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| Order / More Info | Epidermal Growth Factor, Pro-, Recombinant, Mouse (Pro-EGF, EGF) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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