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| Product Name | CD137, Recombinant, Human, aa19-184 |
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| Description | Purity ~98% (SDS-PAGE). Human CD137 (4-1BB) is a costimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. The glycoprotein 4-1BB is expressed mainly on activated CD4+ and CD8+ T cells and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor receptor-associated factors (TRAF), the adaptor protein and mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T cell activation and growth as well as monocyte proliferation and B cell survival, and plays a important role in the amplification of T cell-mediated immune responses. In contrast, it can also enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, the 4-1BB/4-1BBL costimulatory pathway has been sh |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CD137, Recombinant, Human, aa19-184 (Tumor Necrosis Factor Receptor Superfamily Member 9, TNFRSF9, 4-1BB, 4-1BB Ligand Receptor T Cell, Antigen 4-1BB Homolog, T Cell Antigen ILA, CD137 Antigen, CDw137, ILA, MGC2172) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 207102 |
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| Order / More Info | CD137, Recombinant, Human, aa19-184 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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