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| Product Name | CD59, Recombinant, Human, aa26-102 |
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| Description | Purity ~95% (SDS-PAGE). CD59, also known as membrane attack complex inhibition factor (MACIF) and Protectin, is an ~20kD GPIanchored glycoprotein that is an important regulator of the complement system in blood. The complement system triggers innate immune responses to immune complexes, MBL-opsonized microorganisms, and apoptotic cells through the classical, lectin, and alternative pathways. One major consequence of complement activation is the assembly of a membrane attack complex (MAC) composed of one molecule each of complement proteins C5b, C6, C7, and C8 (C5b8) followed by the incorporation of multiple copies of C9 (C5b9). Membrane insertion of the MAC results in formation of a cytolytic pore in the target cell (1). CD59, which is widely expressed on healthy cells, binds to both C8 and C9 and shields them from complementmediated lysis. It inhibits MAC pore formation by blocking C5b8 complex membrane insertion and the incorporation of C9 molecules (24). The binding of CD59 to |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CD59, Recombinant, Human, aa26-102 (HRF20, MACIF, Membrane Attack Complex Inhibition Factor, MIC11, Protectin) |
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| Gene, Accession, CAS # | SwissProt: P13987 |
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| Catalog # | 145780 |
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| Order / More Info | CD59, Recombinant, Human, aa26-102 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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