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| Product Name | BioSim™ anti-Trastuzumab (Herceptin®) (Human) ELISA Kit |
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| Description | Trastuzumab (Herclon®, Herceptin®) is a recombinant DNA-derived humanized monoclonal antibody that selectively targets the extracellular domain of the human epidermal growth factor receptor 2 protein (HER2). Trastuzumab has antitumor activity against HER2-positive human breast tumor cells in laboratory models and is active for the treatment of women with HER2-overexpressing breast cancers. In HER2 overexpressing cells, trastuzumab markedly down-regulates HER2 expression by accelerating receptor endocytosis and degradation and inhibits cell cycle progression by inducing the formation of p27Kip1/Cdk2 complexes. However, some patients develop unwanted immunogenicity, which leads to production of anti-drug-antibodies (ADAs) inactivating |
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| Size | 100 assays |
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| Concentration | n/a |
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| Applications | This ELISA kit is used for quantitative measurement of antibody against Trastuzumab in human serum and plasma |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | E4386-100 |
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| Order / More Info | BioSim™ anti-Trastuzumab (Herceptin®) (Human) ELISA Kit from BIOVISION, INC. |
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| Product Specific References | n/a |
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