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| Product Name | Recombinant Human Charged multivesicular body protein 2a (CHMP2A) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 52.1kDa. Full Length: 1-222aa. N-terminal GST-tagged. Homo sapiens (Human). Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting mbrane of the endosome and mostly are delivered to lysosomes enabling degradation of mbrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating mbrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent mbrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or mbrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Chromatin-modifying protein 2a; CHMP2aPutative breast adenocarcinoma marker BC-2Vacuolar protein sorting-associated protein 2-1; Vps2-1; hVps2-1 |
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| Gene, Accession, CAS # | CHMP2A, UniProt: O43633 |
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| Catalog # | RPC24061 |
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| Order / More Info | Recombinant Human Charged multivesicular body protein 2a (CHMP2A) from BIOMATIK |
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| Product Specific References | n/a |
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