| 产品详情 |
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| Product Name | BMS309403 |
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| Description | Purity >98%. Fatty acid binding protein 4 (FABP4) is a lipid transport protein that is also known as adipocyte FABP and aP2. In addition to adipocytes, it is also abundant in macrophages, along with FABP5, the epidermal FABP. BMS309403 is a cell-permeable, potent inhibitor of FABP4 that targets the fatty acid-binding pocket (Ki < 2 nM). It is less effective against FABP3 and FABP5 (Ki s = 250 and 350 nM, respectively). BMS309403 is orally active, reducing atherosclerosis in mice lacking apoplipoprotein E. It also protects against the development of insulin resistance associated with genetic or diet-induced obesity in mice. FABP4 dose-dependently suppresses the release of MCP-1 from macrophages. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[[2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]-acetic acid, FABP4 Inhibitor, Adipocyte FABP Inhibitor, A-FABP Inhibitor, ALBP Inhibitor, aP2 Inhibitor, Fatty Acid Binding Protein 4 Inhibitor |
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| Gene, Accession, CAS # | CAS: 300657-03-8 |
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| Catalog # | LS-H6861 |
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| Order / More Info | BMS309403 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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