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| Product Name | SM 16 |
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| Description | Potent TGF-β receptor type 1 (TGF-βRI) inhibitor (IC50 = 64 nM in luciferase assay). Selective for TGF-βRI over other ALK family members. Decreases Smad phosphorylation and inhibits tumor growth in a mouse xenograft model. Attenuates increased TGF-β signaling in retinal vessels of diabetic rats. Also prevents intimal thickening and vascular remodeling in rat carotid balloon injury model. Orally bioavailable. Purity 98%. MW (observed): 430.5 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[4-(1,3-Benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide |
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| Gene, Accession, CAS # | CAS: 614749-78-9 |
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| Catalog # | 6245/10 |
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| Price | |
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| Order / More Info | SM 16 from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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