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| Product Name | Recombinant Mouse RAGE/AGER-Fc Chimera (carrier-free) |
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| Description | Receptor for advanced glycation end products (RAGE) or AGER is a multi-ligand receptor that belongs to the immunoglobulin superfamily of cell surface molecules. AGER is a 55kD protein composed of three structural regions; a 320 amino acid extracellular region compromised of a V-type domain and two C-type domains, a 22 amino acid transmembrane spanning helix, and a short 41 amino acid cytosolic domain. AGER can be found in adult lung and skin tissue but low levels are found in other tissue types such as endothelia, cardiomyocytes, neutrophils, macrophages, lymphocytes, dendritic cells, and the central nervous system. AGER activation induces a positive feedback response to AGER leading to an increase in expression of AGER regardless of expression levels. Due to the multi-ligand nature of AGER, the receptor is involved in activation of many cell signal pathways such as ERK1/2, p38, SHPK/JNK MAP Kinases, rho GTPases, phosphoinositol-3-kinase (PI3K), and JAK/STAT. AGER has been found to be involved in pathogenesis and complications that are age related such as diabetes and Alzheimer's, as well as being involved in cellular processes such as inflammation, apoptosis, autophagy, and proliferation.S100 family proteins are small calcium binding proteins with high structural homology that are known to be ligands for AGER. These proteins promote cell growth via p38 MAPK and P44/42 kinase activation in tumor cells and mediate endotoxin induced cardiomyocyte dysfunction in an AGER dependent manner. They are also found to amplify pro-inflammatory cytokine production via the activation of NF-kB and P38 MAPK in an AGER dependent manner as well. S100A12 protein, a member of the S100 protein family, is found in neutrophils, monocytes and lymphocytes and is shown to be strongly expressed in inflammatory diseases such as Crohn's disease, cystic fibrosis, atherosolerosis, and shows RAGE dependent activation as well. |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | AGER, Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end product, RAGE |
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| Gene, Accession, CAS # | Gene ID: 11596 |
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| Catalog # | 783102 |
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| Order / More Info | Recombinant Mouse RAGE/AGER-Fc Chimera (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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