| 产品详情 |
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| Product Name | Dacarbazine |
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| Description | A DNA alkylating prodrug; converted into a methyldiazonium cation that alkylates DNA at all phases of the cell cycle and induces apoptosis; inhibits the growth of B16/F1, A-875, and SK-MEL-5 melanoma and non-cancerous WI-38 lung fibroblast and L-02 hepatocyte cell lines (IC50s = 260, 287, 380, 526, and 367 µM, respectively); toxicity to 518A2 and SK-MEL-28 melanoma cell lines increases in a time-dependent manner (IC50s = 121 and >400, respectively, at 1 hour and 2.5 and 50 µM, respectively, at 96 hours); decreases tumor volume by 59.1% in a B16/F1 murine melanoma model in mice (70 mg/kg, once every 2 days) |
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| Size | 1 g |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | NCI C04717|NSC 45388 |
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| Gene, Accession, CAS # | CAS: 4342-03-4 |
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| Catalog # | 21877-1 |
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| Price | |
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| Order / More Info | Dacarbazine from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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