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| Product Name | Recombinant Human Lysine-specific demethylase 5A (KDM5A) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 35.3kDa. Full Length of Mature Protein: 437-603aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Histone dethylase that specifically dethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not dethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Dethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone dethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Histone demethylase JARID1AJumonji/ARID domain-containing protein 1ARetinoblastoma-binding protein 2; RBBP-2 |
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| Gene, Accession, CAS # | KDM5A, UniProt: P29375 |
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| Catalog # | RPC21556 |
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| Order / More Info | Recombinant Human Lysine-specific demethylase 5A (KDM5A) from BIOMATIK |
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| Product Specific References | n/a |
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