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| Product Name | Interleukin 22R, NT, Blocking Peptide |
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| Description | Purified 60-70%. A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified (1-3). The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family (3,4). IL-22R forms a complex with IL-10 receptor b chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-a 2 (IL-22RA2), was identified very recently (5-7). IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response. Synthetic peptide (QSSNFENILTWDSGPE) corresponding to amino acids 31 to 46 of human IL-22R precursor (1). |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Interleukin 22R, NT, Blocking Peptide (IL-22R NT, CRF2-9, IL-TIF R1, IL-10 Related T Cell-derived Inducible Factor) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | I8443-12P |
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| Order / More Info | Interleukin 22R, NT, Blocking Peptide from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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