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| Product Name | EIF2C2, Recombinant, Human, aa517-818, His-Tag (Protein Argonaute-2) |
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| Description | Purity ~90% (SDS-PAGE). Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complentary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complentarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complentary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complentary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S r |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Argonaute RISC catalytic component 2 |
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| Gene, Accession, CAS # | SwissProt: Q9UKV8 |
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| Catalog # | 373155 |
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| Order / More Info | EIF2C2, Recombinant, Human, aa517-818, His-Tag (Protein Argonaute-2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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