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| Product Name | Recombinant Human Poliovirus receptor (PVR) |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 46.7kDa. Full Length of Mature Protein: 21-417aa. N-terminal 10xHis-tagged. Homo sapiens (Human). Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. Acts as a receptor for pseudorabies virus. Is prevented to reach cell surface upon infection by human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Nectin-like protein 5 |
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| Gene, Accession, CAS # | PVR, UniProt: P15151 |
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| Catalog # | RPC20749 |
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| Order / More Info | Recombinant Human Poliovirus receptor (PVR) from BIOMATIK |
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| Product Specific References | n/a |
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