| 产品详情 |
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| Product Name | Ivacaftor |
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| Description | MW: 392.49. Purity ≥98% by HPLC. Ivacaftor (VX-770) is a potent; cell-permeable small molecule potentiator of cystic fibrosis transmembrane conductance regulator (CFTR). It increases the forskolin-induced CFTR-mediated epithelial current in cells expressing the G551D mutation by ~4-fold (EC50 = 100 nM) but has no effect on current in the absence of forskolin. Ivacaftor increases chloride secretion in cultured human CF bronchial epithelial cells carrying the G551D mutation on one allele and th |
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| Size | 5 mg, 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [N-[2; 4-bis (1; 1-dimethylethyl) -5-hydroxyphenyl]-1; 4-dihydro-4-oxo-3-quinolinecarboxamide; Cystic Fibrosis Transmembrane Conductance Regulator Potentiator; VX770; Kalydeco] |
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| Gene, Accession, CAS # | CAS: 873054-44-5 |
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| Catalog # | MBS845762 |
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| Order / More Info | Ivacaftor from MYBIOSOURCE INC. |
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| Product Specific References | n/a |
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