| 产品详情 |
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| Antigenic Specificity | Human Alas1 |
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| Clone | TB81-15 |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | IgG |
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| Format | unconjugated |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | WB, ICC/IF |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit Anti-Human Alas1 monoclonal antibody for WB, ICC/IF. 5-aminolevulinate synthase 1 (ALAS-H) and 2 (ALAS-E) are two isoforms of ALAS, an enzyme catalyzing the first step of the heme biosynthetic pathway in mammals. The erythroid-specific isoenzyme, ALAS-E, regulates the first step of hematopoietic cell differentation and iron metabolism in the liver. ALAS-H is a housekeeping protein which mediates synthesis of early heme in the mitochondria of most cells. Succinyl CoA associates with ALAS-E in protein conformation change and translocation of ALAS-E into the mitochondria and does not interact with ALAS-H. The ALAS-E 5'-flanking region contains binding sites for nuclear activators such as GATA-1, NF-E2 and EKLF. Since the ALAS gene maps to the X chromosome, mutation of the gene leads to the pyridoxine-refractory X-linked sideroblastic anemia. |
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| Immunogen | Recombinant Protein |
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| Other Names | n/a |
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| Gene, Accession # | Gene ID: 211, UniProt: P13196 |
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| Catalog # | DCABH-4422 |
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| Price | |
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| Order / More Info | Human Alas1 Antibody from CREATIVE DIAGNOSTICS |
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| Product Specific References | n/a |
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| 产品资料 |
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