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| Product Name | KDM5A, Recombinant, Human, aa437-603, His-Tag (Lysine-specific Demethylase 5A) |
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| Description | Purity ~85% (SDS-PAGE). Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1. Source: Recombinant protein corresponding to aa437-603 from human KDM5A, fused to His-Tag at N-t |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Histone demethylase JARID1A Jumonji/ARID domain-containing protein 1A, Retinoblastoma-binding protein 2, RBBP-2 |
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| Gene, Accession, CAS # | SwissProt: P29375 |
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| Catalog # | 373909 |
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| Order / More Info | KDM5A, Recombinant, Human, aa437-603, His-Tag (Lysine-specific Demethylase 5A) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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