| 产品详情 |
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| Product Name | Interleukin 13 (IL13) (C-Term) protein (His tag) |
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| Description | Recombinant Mouse Interleukin-13/IL-13 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Pro22-Phe131) of Mouse IL-13 fused with a polyhistidine tag at the C-terminus. Mouse interleukin 13 (mIL-13) is a pleiotropic cytokine produced by activated Th2 cells. IL-13 induces B cell proliferation and immunoglobin production. It contains a four helical bundle with two internal disulfide bonds. Mouse IL13 shares 58 % sequence identity with human protein and exhibits cross-species activity. IL13 signals via receptor IL13R (type2, IL4R) and activates STAT-6. IL13 initially binds IL-13Rα1 with low affinity and triggers association of IL4Rα, generating a high affinity heterodimeric receptor IL13R and eliciting downstream signals. IL13 also binds IL-13Rα2 with high affinity, which plays a role in a negative feedback system of IL13 signaling. IL13 is an important mediator of allergic inflammation and disease. |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | IL13|IL-13|P600|Il-13|L13 |
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| Gene, Accession, CAS # | Gene ID: 16163 |
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| Catalog # | ABIN1691699 |
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| Order / More Info | Interleukin 13 (IL13) (C-Term) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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