| 产品详情 |
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| Antigenic Specificity | Human c-Abl (phospho Tyr89) |
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| Clone | D.746.0 |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | IgG |
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| Format | unconjugated |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | ChIP, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit Anti-Human c-Abl (phospho Tyr89) monoclonal antibody for ChIP, WB. The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. |
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| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pTyr89 of human c-Abl |
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| Other Names | n/a |
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| Gene, Accession # | Gene ID: 25, UniProt: P00519 |
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| Catalog # | CABT-L1176 |
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| Price | |
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| Order / More Info | Human c-Abl (phospho Tyr89) Antibody from CREATIVE DIAGNOSTICS |
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| Product Specific References | n/a |
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