| 产品详情 |
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| Antigenic Specificity | Human CASP1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | unconjugated |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | IHC-P |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit Anti-Human CASP1 polyclonal antibody for IHC-P. Caspase-1/ICE (Interleukin-1Beta Converting Enzyme) is expressed as a proenzyme of 45kDa in many tissues. Upon stimulus, it gets activated by proteolytic cleavage. Active caspase-1 is a tetramer of two subunits p10 and p20 in 2; 2 proportion. Caspase-1 (cystein aspartic-specific protease 1) cleaves its substrates after an aspartate residue. It cleaves Interleukin Beta into its active form which further exerts its proinflammatory effects. Overexpression of caspase-1 can induce apoptosis in fibroblast, which can be inhibited by overexpression of Crm A, a protein from pox virus. |
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| Immunogen | Synthetic peptide |
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| Other Names | n/a |
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| Gene, Accession # | Gene ID: 834, UniProt: P29466 |
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| Catalog # | CABT-L1706 |
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| Price | |
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| Order / More Info | Human CASP1 Antibody from CREATIVE DIAGNOSTICS |
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| Product Specific References | n/a |
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| 产品资料 |
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