| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | Human CASP6 |
|---|
| Clone | TO18-37 |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG |
|---|
| Format | unconjugated |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | WB, IP |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Rabbit Anti-Human CASP6 monoclonal antibody for WB, IP. A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, Ced-3/caspase-1, is comprised of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6, caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9 and caspase-10. Ced-3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Poly(ADP-ribose) polymerase plays an integral role in surveying for DNA mutations and double strand breaks. Caspase-3, caspase-7 and caspase-9, but not caspase-1, have been shown to cleave the nuclear protein PARP into an apoptotic fragment. Caspase-6, but not caspase-3, has been shown to cleave the nuclear lamins which are critical to maintaining the integrity of the nuclear envelope and cellular morphology. Caspase-10 has been shown to activate caspase-3 and caspase-7 in response to apoptotic stimuli. |
|---|
| Immunogen | Recombinant Protein |
|---|
| Other Names | n/a |
|---|
| Gene, Accession # | Gene ID: 839, UniProt: P55212 |
|---|
| Catalog # | CABT-L760 |
|---|
| Price | |
|---|
| Order / More Info | Human CASP6 Antibody from CREATIVE DIAGNOSTICS |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|