| 产品详情 |
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| Antigenic Specificity | Human c-Cbl (phospho Tyr774) |
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| Clone | 9I5M2 |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | IgG |
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| Format | unconjugated |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | ICC, IF, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit Anti-Human c-Cbl (phospho Tyr774) monoclonal antibody for ICC, IF, WB. Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling. |
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| Immunogen | Peptide corresponding to Human CBL (aa 770-778) |
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| Other Names | n/a |
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| Gene, Accession # | Gene ID: 867, UniProt: P22681 |
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| Catalog # | CABT-L1219 |
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| Price | |
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| Order / More Info | Human c-Cbl (phospho Tyr774) Antibody from CREATIVE DIAGNOSTICS |
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| Product Specific References | n/a |
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