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| Antigenic Specificity | RPN-I |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, canine, rat |
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| Isotype | n/a |
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| Format | unconjugated |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit Anti-Human RPN-I polyclonal antibody for WB. Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 1 (EC 2.4.99.18; UniProt P04843; also known as Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 67 kDa subunit, Ribophorin I, RPN-I, Ribophorin-1) is encoded by the RPN1 gene (Gene ID 6184) in human. Ribophorin I is an ER transmembrane protein and a subunit of the mammalian Oligosaccharyltransferase (OST) complex. Ribophorin I binds newly synthesized target proteins and delivers them to the catalytic core of the OST complex. Association of ribophorin I with newly synthesized membrane proteins was observed after the exit of the nascent chain from the Sec61 translocon, and it was unaffected by the N-glycosylation status. Ribophorin I is reported to preferentially interact with misfolded over native ribonuclease A. In addition, Ribophorin I is shown to complex with another ER protein malectin and enhance malectins ability to prevent the secretion of the folding-defective proteins. |
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| Immunogen | KLH-conjugated linear peptide corresponding to the C-terminal sequence of human Ribophorin I/RPN-I. |
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| Other Names | n/a |
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| Gene, Accession # | Gene ID: 6184, UniProt: P04843 |
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| Catalog # | CABT-B1555 |
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| Price | |
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| Order / More Info | RPN-I Antibody from CREATIVE DIAGNOSTICS |
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| Product Specific References | n/a |
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